Effects of Trace Elements and Antioxidant Status in Subjects with Coronary Heart Disease

Oxidative damage is known to cause deleterious effects on cellular function leading to a number of disease conditions. Involvement of oxygen radical has been suggested in many clinical conditions including Coronary Heart Disease (CHD). The present investigation describes the lipid profile, trace element profile, SOD, catalase activity and lipid peroxidation in CHD patients in the age group between 40-60 years. The concentration of cholesterol, LDL, TG, and VLDL were found to be increased when compared to the control, where as the levels of HDL decreased, when compared to the control. Concentration of Iron, Copper and Albumin Cobalt binding Absorbance (ABSU) were elevated in CHD as compared to the control. Total Iron Binding Capacity (TIBC) and Zn were found to be decreased in CHD. Lipid peroxidation as measured by the level of MDA was increased, where as SOD and catalase activities was decreased in CHD condition.